Pharmaceutical Grade Polyanionic Cellulose PAC

Pharmaceutical grade polyanionic cellulose (PAC) has a wide range of uses. In the field of pharmaceuticals, it is a preparation excipient with the ability to thicken, bond and suspend. In tablet preparation, PAC can be used as a binder to bond drug powders into a stable tablet, maintaining its morphology and easy to swallow. And it has disintegration. When it encounters body fluids, the tablet disintegrates to dissolve and absorb the drug. It can also be a suspending agent. In suspensions, the drug particles are evenly dispersed, preventing sedimentation and stabilizing the quality of the preparation. In the food industry, PAC is used as a thickener and stabilizer. In beverages, increase its viscosity, change the taste, and distribute the suspended ingredients evenly; in jams and jellies, adjust the texture consistency, maintain the stability of the form, and prolong the shelf life. In oil drilling, PAC is a mud treatment agent. It can increase the viscosity and shear force of the mud, make the drilling cuttings suspended, facilitate discharge, and reduce the amount of filtration loss, maintain the stability of the well wall, prevent collapse, and improve drilling efficiency and safety. In the daily chemical industry, PAC is used in toothpaste, shampoo, etc. In toothpaste, it is used as a thickener and stabilizer to maintain the shape of the paste, regulate the extrusion and taste; in shampoo, it increases the viscosity and helps the active ingredients to disperse, improving the stability and sense of use of the product. In the paper industry, PAC is used as a paper reinforcer to improve the physical properties of paper, such as tensile strength and burst resistance. It can also be used as a surface sizing agent to improve the surface properties of paper, increase smoothness and water resistance.

Pharmaceutical grade polyanionic cellulose (PAC) does have many extraordinary things compared to other similar products. First, the solubility of PAC is very good. Looking at ordinary similar products, when dissolved in water, it may require long-term stirring, or it is difficult to form a uniform state. However, PAC is easily soluble in contact with water, instant and evenly dispersed, just like a stream flowing into a river and blending in an instant, which can greatly improve production efficiency. In the pharmaceutical process, it is particularly critical, saving a lot of time and manpower. Second, the thickening performance of PAC is excellent. Although other products also have the power of thickening, the thickening effect of PAC is more significant. In the solution, it can quickly build a stable network structure, like a densely woven network, so that the viscosity of the liquid is just right. Whether it is an oral preparation or an external paste, it can maintain good physical properties and ensure the stable quality of the drug. Third, the stability of PAC is excellent. In the face of changes in environmental factors such as temperature and pH, other similar products or performance is greatly reduced, or the structure disintegrates. And PAC is like a rock, able to stick to its own characteristics, regardless of the environment, hot and cold, acid and alkali, it can remain stable, providing a solid guarantee for the long-term storage and use of the drug. Fourth, the compatibility of PAC is excellent. When making a drug, it needs to be coordinated with a variety of ingredients. Other substances may conflict with other ingredients, affecting the efficacy. However, PAC is like a sage of affinity, able to coexist harmoniously with various drug ingredients, without disturbing the efficacy, and can help the ingredients of the drug to exert their functions and form a good medicine. In summary, pharmaceutical-grade polyanionic cellulose PAC has unique advantages over other similar products in terms of solubility, thickening, stability and compatibility. It is a rare product in the pharmaceutical field.

Pharmaceutical grade polyanionic cellulose (PAC), its Quality Standard is the key. To observe this quality, the first purity is required, and high purity products must be required, and impurities must be few, so as to meet the regulations for medicinal use. Its purity is often very high to ensure the safety of medicine. The second viscosity, the viscosity is related to its dispersion and stability in the drug. Different pharmaceutical uses require different viscosity. For example, liquid preparations, the viscosity needs to be adapted to make the drug evenly dispersed and palatable; solid preparations also depend on their appropriate viscosity, auxiliary molding, disintegration, etc. Furthermore, the particle size distribution should not be underestimated. The uniform particle size facilitates its uniform mixing during the preparation process, and has an impact on the dissolution rate of the drug. The small and uniform particle size can promote its rapid dissolution and dispersion, which is very helpful for the efficacy of the drug. Solubility is also an important standard. In water and commonly used medicinal solvents, when there is good solubility, it can be integrated with other medicinal ingredients to form a uniform and stable system. In addition, the microbial limit is also strictly required. Medicinal materials must never tolerate the growth of microorganisms, and must meet the established microbial limit standards to ensure drug safety and prevent infection of bacteria from causing damage to patient health. All these standards are the key to the quality of pharmaceutical-grade polyanionic cellulose (PAC), which can be safely and effectively applied in the pharmaceutical field.

Pharmaceutical grade polyanionic cellulose (PAC) requires many important principles for storage. Its sex is delicate, and it should be placed in a dry place. Avoiding moisture is the first priority. If it encounters moisture, PAC is easy to absorb moisture, causing changes in properties, or agglomerating into clumps, losing its inherent properties, and its efficacy is also affected. And the temperature of the storage place also needs to be paid attention to. Room temperature is appropriate, and extreme cold and heat are avoided. If it is too cold, the molecular structure will be stiff and the activity will be reduced; if it is overheated, it may cause decomposition and deterioration, and the efficacy will not be complete. Furthermore, avoiding light is also the key. The illumination of light, or the introduction of chemical reactions, will damage the integrity of its molecules. Therefore, it should be hidden in a dark room, or in a light-shielding device. And there should be no filth or odor around it. If it coexists with odor or dust, or is stained with odor, or contaminated, the quality will be greatly reduced. It should be stored in a purifier and separated from other things to keep it pure. In addition, when storing, do not stack too high. Under heavy pressure, PAC may cause physical deformation, affecting the access and dispersion properties. Following these rules can ensure the long-term storage of pharmaceutical-grade polyanionic cellulose, and it can be used in the pharmaceutical industry.

The preparation method of pharmaceutical grade polyanionic cellulose (PAC) is quite exquisite. The first refined cotton is taken as the foundation. Put it into the reactor, accompanied by an appropriate amount of sodium hydroxide solution, to make it fully swollen, this step is to pave the way for the subsequent reaction. When swelling, it is necessary to strictly control the temperature and time. The temperature is suitable for a specific range, and the time must also be precisely controlled to make the refined cotton reach the best swelling state. Then, add etherification agent, and the amount of etherification agent should be accurately proportioned. In the etherification reaction, temperature, pressure and reaction time are all key. Increasing the temperature can accelerate the reaction, but if it is too high, it will fear side reactions, so the temperature must be stable in the appropriate range. The same is true of pressure, which needs to be maintained at an appropriate level to ensure a smooth reaction. After this etherification reaction, the molecular structure of cellulose is gradually changed, and a polyanionic group is introduced. After the reaction is completed, a crude product is obtained. This product still contains impurities and must be refined. Wash with a specific solvent to remove unreacted raw materials, by-products and other impurities. The number of times of cleaning and the amount of solvent used are fixed, and more will damage the product, and less impurities will be difficult to clean. After the separation and drying process, when separating, choose a suitable separation method to distinguish the product from the cleaning liquid. When drying, temperature control is also a priority, and improper temperature may cause damage to the quality of the product. The final product is pharmaceutical-grade polyanionic cellulose (PAC), which is of high quality and meets the stringent standards required for pharmaceuticals.